{"id":13394,"date":"2020-10-15T09:07:06","date_gmt":"2020-10-15T14:07:06","guid":{"rendered":"https:\/\/www.missouriwestern.edu\/ctl\/?p=13394"},"modified":"2020-10-15T17:23:15","modified_gmt":"2020-10-15T22:23:15","slug":"13394","status":"publish","type":"post","link":"https:\/\/www.missouriwestern.edu\/ctl\/2020\/10\/15\/13394\/","title":{"rendered":""},"content":{"rendered":"<div class=\"fusion-text\">\n<div class=\"fusion-text\">\n<p><strong>Amit Verma (Business), Mark Lewis (Business), and Todd Eckdahl (Biology), \u201cQfold: A New Modeling Paradigm for the RNA Folding Problem\u201d<\/strong><\/p>\n<\/div>\n<div class=\"fusion-text\">\n<div class=\"video-shortcode\"><iframe title=\"Amit Verma (Business), Mark Lewis (Business), Todd Eckdahl (Biology), &quot;Qfold Modeling&quot;\" width=\"1778\" height=\"1000\" src=\"https:\/\/www.youtube.com\/embed\/NGK3_TUf8TE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n<p>Abstract: Ribonucleic Acid (RNA) molecules play informational, structural, and metabolic roles in all living cells. RNAs are chains of nucleotides containing bases {A,C,G,U} that interact via base pairings to determine higher-order structure and functionality. The RNA folding problem is to predict one or more secondary RNA structures from a given primary sequence of bases. From a mathematical modeling perspective, solutions to the RNA folding problem come from minimizing the thermodynamic free energy of a structure by selecting which bases will be paired, subject to a set of constraints. Here we report on a Quadratic Unconstrained Binary Optimization (QUBO) modeling paradigm that fits naturally with the parameters and constraints required for RNA folding prediction. Three QUBO models are presented along with a hybrid metaheuristic algorithm. Extensive testing results show a strong positive correlation with benchmark results.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Amit Verma (Business), Mark Lewis (Business), and Todd Eckdahl (Biology), \u201cQfold: A New Modeling Paradigm for the RNA Folding Problem\u201d Abstract: Ribonucleic Acid (RNA) molecules play informational, structural, and metabolic roles in all living cells. RNAs are chains of nucleotides containing bases {A,C,G,U} that interact via base pairings to determine higher-order structure and functionality. The [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[451],"tags":[],"_links":{"self":[{"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/posts\/13394"}],"collection":[{"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/comments?post=13394"}],"version-history":[{"count":3,"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/posts\/13394\/revisions"}],"predecessor-version":[{"id":13410,"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/posts\/13394\/revisions\/13410"}],"wp:attachment":[{"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/media?parent=13394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/categories?post=13394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.missouriwestern.edu\/ctl\/wp-json\/wp\/v2\/tags?post=13394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}