Department of Chemistry

Dr. Stan Svojanovsky

Assistant Professor and Department Graduate Director

B.S., University of Pardubice (Czech Republic)
M.S., Western Michigan University
Ph.D., University of Kansas

816-271-4125
Agenstein Hall, 332
ssvojano@missouriwestern.edu

Research Interests:

Development of analytical assays to quantify anticancer drugs in physiological fluids.
Development of methods for the identification of antitumor drugs analogs.
Publications
Svojanovsky SR, Egodage K, Wu J, Slavik M, Wilson GS. (1999). High sensitivity ELISA determination of taxol in various human biological fluids. J Pharm Biomed Anal. 20:549-555. PMID: 10701971

Rossier J, Gokulrangan G, Girault H, Svojanovsky SR, Wilson GS. (2000). Characterization of protein adsorption and immunosorption kinetics in photoablated polymer microchannels. Langmuir, 16:8489-8494. DOI: 10.1021/la0006667

Svojanovsky SR, Schneider TD, Rogan PK. (2001). Redundant designation of BRCA1 intron 11 splicing mutation; c.4216-2A>G; IVS11-2A>G; L78833, 37698, A>G. Hum Mutat. 16(3):264. PMID: 10980533

Rogan PK, Svojanovsky SR, Leeder JS. (2003). Information theory-based analysis of CYP2C19, CYP2C6 and CYP3A5 splicing mutations. Pharmacogenetics,13(4):207-18. PMID: 12668917

Werle MJ, Brownback K, VanSaun MN, Rodova M, Svojanovsky SR. (2003) Gene array of four day Denervated mouse gastrocnemius muscle. Society for Neuroscience. http://www.kumc.edu/werlelab/genearray/index.html

Naranatt PP, Krishnan HH, Svojanovsky SR, Bloomer C, Mathur S, Chandran B. (2004). Host gene induction and transcriptional reprogramming in Kaposi’s-sarcoma associated herpesvirus (KSHV/HHV-8) infected endothelial, fibroblast and B cells: insights into modulation events early during infection. Cancer Res. 64(1):72-84. PMID: 14729610

Puri V, Puri S, Svojanovsky SR, Mathur S, Macgregor RR, Klein RM, Welch KM, Berman NE. (2006). Effects of oestrogen on trigeminal ganglia in culture: implications for hormonal effects on migraine. Cephalalgia, 26(1): 33-42. PMID: 16396664

Sun A, Tang J, Hong Y, Song J, Terranova PF, Thrasher JB, Svojanovsky S, Wang HG, Li B. (2008). Androgen receptor-dependent regulation of Bcl-xL expression: Implication in prostate cancer progression. Prostate, 68(4):453-61. PMID: 18196538

Truog WE, Xu D, Ekekezie I, Mabry S, Rezaiekhaligh M, Svojanovsky SR, Soares MJ. (2008). Chronic hypoxia and rat lung development: analysis by morphometry and directed microarray. Pediatr. Res. 64(1):56-62. PMID: 18344904

Chakrabarty A, Blacklock A, Svojanovsky SR, Smith PG. (2008). Estrogen elicits dorsal root ganglion axon sprouting via a renin-angiotensin system. Endocrinology, 149(7):3452-60. PMCID: PMC2453086, PMID: 18388195

Walters E, Rider V, Abdou NI, Greenwell C, Svojanovsky S, Smith PG. and Kimler BF. (2009). Estradiol targets T cell signaling pathways in human systemic lupus. Clin. Immunol. 133(3):428-36. PMCID: PMC2783703, PMID:1979368

Mathur S., Visvanathan M, Svojanovsky SR, Yoo B, Srinivas AB, Lushington GH, Smith PG. (2009) GOAPhAR: An interactive discovery tool for annotation and pathway analysis. The Open Bioinformatics Journal, 1;3:26-30.

Chakrabarti S, Svojanovsky SR, Slavik R, Georg GI., Wilson GS, Smith PG. (2010) Artificial neural network-based analysis of high-throughput screening data for improved prediction of active compounds. Journal of Biomolecular Screening;14(10):1236-44. PMID:19940083

Boudrias M-H, Lee S-P, Svojanovsky SR, Cheney PD. (2010). Forelimb muscle representations and output properties of motor areas in the mesial wall of Rhesus Macaques. Cereb Cortex, Mar;20(3):704- 19. PMCID: PMC2820706, PMID:19633176

Svojanovsky SR, Chakrabarti S, Georg G, Wilson G.S. (2011) Design of neural network models for screening anticancer activities in Taxol analogues. Proceedings NETTAB 2011 conference, p 68-71.

Sherzada A, Svojanovsky SR. (2012). An Analysis of ADHD Drugs: Ritalin and Adderall. JCCC Honors Journal: Vol. 3: Iss.1, Article 2. http://scholarspace.jccc.edu/honors_journal/vol3/iss1/2
Presentations
Wu J, Svojanovsky SR, Moore D, Stobaugh J, Slavik M. Pharmacokinetic modeling of taxol administered by clinically used intravenous infusion schedules. Fifth Annual Research Forum, The University of Kansas School of Medicine, Wichita, KS, 1995.

Svojanovsky SR, Wu J, Egodage K, DeSilva B, Slavik M, Wilson GS. The new ELISA method for determination of Taxol subnanogram concentrations in human plasma ultrafiltrate and salivary fluids. The Fifth International Workshop on Bioanalysis, University of Kansas, Lawrence, KS, 1996.

Svojanovsky SR, Wu J, Slavik M, Wilson GS. Application of the newly developed ELISA for taxol pharmacokinetics studies in cancer patients. Sixth Annual Research Forum, The University of Kansas School of Medicine, Wichita, KS 1996.

Svojanovsky SR, Chakrabarti S, Wilson GS. Neural network for predicting the anticancer activity of pharmaceutical compounds. Seventh Annual Research Forum, The University of Kansas School of Medicine, Wichita, KS, 1997.

Slavik M, Wu J, Svojanovsky SR. Reversal of azaribine side effects with administration of pyridoxine in patients with severe psoriasis. Seventh Annual Research Forum, The University of Kansas School of Medicine, Wichita, KS, 1997.

Slavik M, Wu J, Svojanovsky SR. Reversal of azaribine side effects with administration of pyridoxine in patients with severe psoriasis. Seventh Annual Research Forum, The University of Kansas School of Medicine, Wichita, KS, 1997.

Wu J, Svojanovsky SR, Stobaugh J, Slavik M. Clinical pharmacokinetic studies of etoposide (VP16). Seventh Annual Research Forum, The University of Kansas School of Medicine, Wichita, KS, 1997.

Hesketh PJ, Zivanovic S, Ming SY, Pak SC, Svojanovsky SR, Cunneen JC, Caraffini S, Boyd JG, Stetter JR, Lunte SM, Wilson GS. Microfabricated Biosensors and Microsystems. Proceedings of the 21st International Conference on Microelectronics, (MIEL'97) Nis˜ , Yugoslavia, 14-17th September, 1997.

Svojanovsky SR, Rogan PK. Tumor suppressor function of the BRCA1 gene has a low threshold for mutation. American Society of Human Genetics, Philadelphia, PA, October 2000.

Kodolitsch YV, Schalwat I, Svojanovsky SR, Berger E, Rogan PK. Relationship of splice site information content to severity of hemophilia A and B. American Society of Human Genetics, Philadelphia, PA, October 2000.

Svojanovsky SR, Hobson GM, Sperle K, Sistermans EA, Garbern JY, Rogan PK. Predicted expression of PLP splicing mutations in Pelizaeus-Merzbacher disease. American Society of Human Genetics, New Orleans, LA, October 2001.

Hurwitz I, Svojanovsky SR, Rogan PK, Leeder JS. Modulation of constitutive CYP2D6 activity: differential binding of NF-B P50 to the –1496C and –1496G variants. 6th Annual Meeting of the International Society for Study of Xenobiotics, Munich, Germany, October 2001.

Tazelaar J, Uhrmacher J, Svojanovsky SR, Rubinstein W, Myers E, Rogan PK, Baysal B, Kant J. Hereditary Paraganglioma: Validation and Early Diagnostic Experience. Association for Molecular Pathology. San Diego, CA, November 2001.

Cambi F, Huang Z, Rogan PK, Svojanovsky SR, Davis-Williams A, Sperle K, Lewis D, Hobson G. Mutations that reduce PLP-specific splicing affect myelin and axonal integrity. American Neurology Association, Plenary Session, Boston, MA, October, 2002.

Rogan PK, Svojanovsky SR, Hurwitz I, Schneider TD, Leeder JS. Model splice site and transcription factor binding site variation by information theory. American Society of Human Genetics, Boston, MA, October 2002.

Smith PG, Baum LL, Krizsan-Agbas D, Pedchenko T, Svojanovsky SR. Effects of estrogen on cultured sympathetic neurons. Society for Neuroscience, New Orleans, LA, November, 2003.

Svojanovsky SR, Chakrabarti S, Wilson GS, Smith PG, Georg G. Neural Network Applications in Anticancer Drug Development. 1st Kansas IdeA Biomedical Focus Group Symposium, The University of Kansas, Lawrence, KS, November, 2003.

Werle, MJ Brownback K, VanSaun MN, Rodova M, Svojanovsky SR. Gene array of four day denervated mouse gastrocnemius muscle. Society for Neuroscience, New Orleans, LA, November, 2003.

Svojanovsky SR, Chakrabarti S, Smith PG. Taxol Analogues – Predicting Antitumor Activities with Neural Network. EPSCoR State Conference on Bioinformatics and Biomedical Computing, Omaha, NE, April 16, 2004.

Svojanovsky SR, Chakrabarti S. Neural Networks in Anticancer Drug Development. CHI, Beyond Genome-Bioinformatics and Genome Research Conference, San Francisco, CA, June 19, 2004.

Taglauer E, Svojanovsky SR, Petroff MG. Oxygen-Mediated Gene Regulation in Placental Cytotrophoblast Cells. The Gilbert S. Greenwald Symposium on Reproduction. Kansas City, MO, September 12, 2004.

Mathur S, Smith PG, Svojanovsky SR. A New Web-based Application for Annotation and Biological Pathway Analysis of Microarray Data. The Third Annual K-INBRE Student Symposium, The University of Kansas, Lawrence, KS, January 15-16, 2005.

Chen J, Mathur S, Smith PG, Svojanovsky SR. Protein Secondary Structure Prediction using Artificial Neural Network. IDeA Networks of Biomedical Research Excellence (INBRE), Regional Meeting, Kansas City, KS, May 5-6, 2005.

Hebar M, Svojanovsky SR, Lushington GH, Georg G, Smith PG, Chakrabarti S. Artificial Neural Network in High Throughput Screening-Classifying the Activity Toward Cobalt. Beyond Genome: The Future of Medicine, San Francisco, CA, June 14, 2005.

Hebar M, Svojanovsky SR, Qi-Zhuang Y, Georg G, Smith PG, Chakrabarti S. Artificial Neural Networks in High Throughput Screening. Kansas City Area Life Sciences Research Day, Kansas City Convention Center, Kansas City, MO, March 29-30, 2006.

Svojanovsky SR, Kover KR, Wyckoff JD, Moore WJ. Gene expression profile of Patients with new onset type 1 diabetes. Kansas City Area Life Sciences Research Day, Kansas City Convention Center, Kansas City, MO, March 29-30, 2006.

Banz B, Svojanovsky SR, Hebar M., Chakrabarti S, Georg G, Smith PG. Fuzzy Neural Networks parallel to HTS. KUMC Faculty Research Day and Poster Session, November 9, 2006.

Svojanovsky SR: Computer Assisted Drug Design: New Perspectives in Anticancer Drug Discovery JCCC, Overland Park, KS, Jan. 12, 2007

Redford C, Svojanovsky SR, Chakrabarti S, Georg G, Wilson GS, Smith PG. Computer Assisted Drug Design: Strategy for Anticancer Drug Development. Fifth Annual K-INBRE Symposium, Kansas City, KS. January 13-14, 2007.

Kover KR, Svojanovsky SR, Wyckoff JD, Moore WJ. Gene expression profile of Patients with new onset type 1 diabetes. American Diabetes Association, Boston, MA, June 2007.

Walters E, Rider V, Abdou N, Svojanovsky SR, Smith PG 2008. Microarray profiling of estrogen- dependent genes in systemic Lupus Erythematosus. The Sixth Annual K-INBRE Symposium, Kansas City, KS. January 19-20, 2008.

Truog WE, Xu D, Rezaiekhaligh M, Mabry S, Soares M, Svojanovsky SR, Ekekezie I. Effects Of Hypoxia On Rat Pup Lung Development: Whole Genome Expression And Directed Protein Analyses. Pediatric Academic Societies’ Meeting, August 2-5, 2008.

Hendry WJ, Hendry IR, Svojanovsky SR. Altered gene expression patterns during the initial and promotional stages of neonatal diethylstilbestrol-induced dysplasia/neoplasia in the hamster uterus. The Seventh Annual K-INBRE Symposium, Manhattan, KS. January 17-18, 2009.

Walters E, Rider V, Abdou NI, Greenwell C, Svojanovsky SR, Smith PG. Estrogen Upregulates the Interferon-α Pathway in T Cells of Women With Systemic Lupus Erythematosus. American Society for Cell Biology, San Francisco, CA, December 2009.

Truog WE, Svojanovsky SR, Bloomer C, Norberg M, Smith PG. Single Nucleotide Polymorphisms (SNPs) and BPD: Possible New Associations. Meeting of the Pediatric Academic Societies, May 2010.

Svojanovsky SR: Microarray Technology in Biomedical Research JCCC, Overland Park, KS, Feb.1, 2011.

Svojanovsky SR: Artificial Intelligence Application on Computer-Assisted Molecular Design, JCCC, Overland Park, KS, Feb. 3, 2011.

Svojanovsky SR: Genomic Expression Analysis at KUMC: Bioinformatics, Microarrays and Biomedical Research, JCCC, Overland Park, KS, Feb. 10, 2011.

Svojanovsky SR: Bioinformatics and Biomedical Research at KUMC, Pittsburg State University (PSU), April 27, 2011.

Svojanovsky SR, Chakrabarti S, Georg G, Wilson GS. Design of neural network models for screening anticancer activities in Taxol analogues. Oral presentation at NETTAB Conference in Clinical Bioinformatics, Collegio Ghislieri, Pavia, Italy, October 12-14, 2011.